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Advantages of BIOPHENTM DTI

The chromogenic BIOPHEN™ DTI offers important advantages over coagulometric assays in the quantitative determination of direct thrombin inhibitors.


  • High reagent stability after reconstitution:
    4 weeks at 2-8°C, 2 months at ≤ -20°C,
    up to 10 days on board (device dependent)
  • No heparin interference up to 2 IU/mL; direct Xa-inhibitors up to 400 ng/mL
  • Highly sensitive (cf. analyte-table below)
  • Excellent comparability with Hemoclot®
    thrombin inhibitor and LCMS
  • CE-certified for quantitative measurement of
    Dabigatran (Pradaxa®), Argatroban (Argatra®),
    Bivalirudin (Angiox®) and Hirudin.
  • Validated applications available for all common analyzers.
  • Test duration: < 5 minutes

BIOPHENTM DTI 

 

R1: Thrombin specific chromigenic substrate, 2x2.5 mL
R2: Human thrombin, 2x2.5 mL,
R3: Tris-BSA-Buffer, 2x25 mL

Analyte
Argatroban (Argatra®)      
Dabigatran (Pradaxa®)      

measuring range
approx. 0-2 μg/mL
approx. 0-500 ng/mL         

LOD
< 0.05 μg/mL
< 10 ng/mL

    

>> Download IFU: BIOPHENTM DTI

 

Referenzen:
- Amiral et al., An update on laboratory measurements of Dabigatran: Smart specific and calibrated dedicated assays
  for measuring anti-IIa activity in plasma; Transfusion and Apheresis Science 54 (2016) 428–437.
- Poli et al., Diagnostic Accuracy of a Novel Chromogenic Direct Thrombin Inhibitor Assay:
  Clinical Experiences for Dabigatran Monitoring; Thromb Haemost 2017;117: 2369–2375.