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Measurement of fibrinogen in plasma. Detection of low fibrinogen concentrations. Detection of elevated fibrinogen concentrations (> 4g/L): In clinical situations associated with inflammation Risk factor for cardiovascular disease and thrombosis Hypofibrinogenemia, mainly associated with severe liver disease, and excessive consumption of fibrinogen (DIC, hyperfibrinolysis). Numerous variants of fibrinogen described, associated to asymptomatic cases, or to cases with bleeding and/or thrombosis.

Conventional thrombin time, highly sensitive to heparins and thrombin inhibitors.

Conventional thrombin time, highly sensitive to heparins and thrombin inhibitors.

Coagulation assays, such as the activated partial thromboplastin time (aPTT) or for the assays of factors of the intrinsic coagulation pathway.

Heparin studies.

Heparin studies.

For any in vitro protocol or research study where a source of human TAFI deficient plasma is required.

High TAFI Ag concentrations involve a hypofibrinolytic status, which can induce an elevated risk of thrombosis. Measurement of TAFI Ag on plasma in order to diagnose a risk of a hypofibrinolysis resulting from an excess of TAFI.