Fibrinolysis

Physiological fibrinolysis means the cleavage of fibrin by the enzyme plasmin. The fibrinolytic system, i.e. the degradation of fibrin, must be in a state of equilibrium with the coagulation system, which provides fibrin deposits.

For the determination of plasminogen activity, we supply our chromogenic assay BIOPHEN™ Plasminogen LRT. For investigating the most important plasminogen activator tissue plasminogen activator (TPA), our plate-based ZYMUTEST™ tPA Antigen ELISA and ZYMUPHEN™ tPA Acitvity chromogenic assay are suitable solutions.

Same as the coagulation system, the fibrinolytic system is kept under control by inhibitors (PAI-1, alpha-2-antiplasmin). For investigating these inhibitors, our following test kits are suited:

• BIOPHEN™ Alpha-2-Antiplasmin (Plasmin-Inhibitor) LRT
• ZYMUTEST PAI-1 Activity
• ZYMUTEST™ PAI-1 Antigen