CoaChrom Diagnostica GmbH
Stolzenthalergasse 6
1080 Vienna, Austria
Tel.: +43-(0)1-699 97 97
Fax: +43-(0)1-699 18 97
eMail:
 
 
 
NEWS
 

HYPHEN BioMed
The Pioneer in Haemostasis
 

ZYMUTEST HIA kits

offer a range of immuno-assays designed for testing heparin dependent antibodies, involved in the development of Heparin Induced Thrombocytopenia (HIT) or Heparin Induced Thrombocytopenia and Thrombosis (HITT).

  
     
BIOPHEN FACTOR IX

BIOPHEN Factor IX kit is a chromogenic assay for measuring Factor IX activity in human citrated plasma or in Factor IX concentrates, using a chromogenic method, manual or automated.
 
  BIOPHEN FACTOR IXa

BIOPHEN Factor IXa (ACT. FIX) kit is thefirst chromogenic assay for measuring activated Factor IX (FIXa) activity, using a chromogenic method, manual or automated.
 
Literature 1. van Hylckama Vlieg A, van der Linden IK, Bertina RM, Rosendaal FR, “High levels of factor IX increase the risk of venous thrombosis”, Blood, 95(12): 3678-82, 2000.

2. Taran LD, “Factor IX of the blood coagulation system: a review”, Biochemistry (Mosc.),62(7):685-93, 1997.

3. Wagenvoord R, Hendrix H, Tran T, Hemker HC, “Development of a sensitive and rapidchromogenic FIX assay for clinical use”, Haemostasis, 20(5): 276-88, 1990.

4. Parekh VR, Mannucci PM, Ruggeri ZM, “Immunological heterogeneity of haemophilia B: amulticentre study of 98 kindreds”, Br J Haematol, 40(4): 643:55, 1978.

5. Orstavik KH, Veltkamp JJ, Bertina RM, Hermans J, “Detection of carriers of haemophilia B”, Br J Haematol, 42(2): 293-301, 1979.

 
MICROPARTICLES ASSAY

Novel assay for quantitatively measuring microparticles
procoagulant activity in human citrated plasma.

Microparticles are released from some blood cells, mainly platelet or endothelial cells, but also from monocytes or lymphocytes, upon cell
activation. They frequently expose phosphatidyl serine, which focuses initiation of blood coagulation pathways.

Microparticles are the markers arising as a consequence of the disease, but can also be the cause of worsening of the disease through their
procoagulant activity.
 
Literature Microparticles Assay - by A.M. Vissac and J. Amiral
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  Package Insert
>> more
 
Literature Injection of recombinant activated factor VII can induce transient increase in circulating procoagulant microparticles
  The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection
  The relationship between plasma microparticles, protein S and anticardiolipin antibodies in patients with human immunodeficiency virus infection.
  Cellular microparticles: what are they bad or good for?
  Protective effets of vitamin C on endothelium damage and platelet activation during myocardial infarction in patients with sustained generation of circulating microparticles
  Cellular microparticles: a disseminated storage pool of bioactive vascular effectors
  Cellular origins and thrombogenic activity of microparticles isolated from human atherosclerotic plaques
 
Further News Calibration and Control Plasmas  
  For Biophen Heparin 3 and Biophen Heparin 6:
222501, Arixtra Calibrator, 0,0 – 1,5 µg/ml
224001, Arixtra Control, 0,40 and 1,20 µg/ml
  Direct Thrombininhibitors  
  SC030K, Argatroban Calibrator, 0,0 – 2,0 µg/ml
SC035K, Argatroban Control, 0,65 and 1,25 µg/ml
CK002K, Hemoclot Thrombin Inhibitors, 3 x 30 tests

>> more
>> more
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  Prothrombin, chromogenic Assay
  Hirudin Standards and Controls (Low)
  Hirudin Standards and Controls (High)
  Factor IX ELISA (Zymutest FIX)
  Protein Z ELISA
  BIOPHEN® Factor X, chromogenic Assay
PL TGT Emulsion

Highly stable phospholipid emulsions are suitable for use in haemostasis research related to procoagulant and anticoagulant pathways.

The Phospholipid-TGT is specially suitable for use in thrombin generation (TGT) assays.
 
Literature 1. A.W.J.H Dielis, E. Castoldi, H.M.H. Spronk, R. van Oerkle, K. Hamulyák, H. Ten Cate, J. Rosing Coagulation factors and the protein C system as determinants of thrombin generation in a normal population. Journal of Thrombosis and Haemostasis 6 (1), 125-131 (2008)

2. S.N Tchaikovski, B.J.M van Vljimen, J. Rosing, G. Tans Development of a calibrated automated thrombography based thrombin generation test in mouse plasma Journal of Thrombosis and Haemostasis 5 (10), 2079-2086 (2007) 

3. N. Li, S. He, M. Blombäck, P. Hjemdahl Platelet activity, coagulation and fibrinolysis during exercise in healthy males. Effects of thrombin inhibition by argatroban and enoxaparin. Arteriosclerosis, Thrombosis, and Vascular Biology. 27, 407 (2007)

4. C. Gardiner, S.J. Machin, I.K. Mackie Measuring thrombin generation based sensitivity to activated protein C using an automated coagulometer (ACL 9000) International Journal of Laboratory Hematology (OnlineEarly Articles)		  
 
Raven Biological Laboratories
Biological and chemical Indicators
 


Snap frozen plasmas
snap frozen, not lyophilized control and deficiency plasma:
better representation of your patient samples
easy handling
enhanced precision and accuracy
 
Prekallikrein Fraction Pool
Art.No. COA0022 2.0 mL, lyophilized
Prekallikrein substrate acc. to Pharm.Eur.1997. 2.6.15 (Preparation of Prekallikrein substrate) for the determination of Prekallikrein Activator in human albumin and immunglobulin preparations.
 
 
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